Overview & mechanism
GHK-Cu (Glycyl-L-Histidyl-L-Lysine-copper) is a tripeptide with high affinity for copper (II) that naturally declines with age. Research has examined its role in collagen and elastin synthesis, antioxidant defense, wound remodeling, and follicle stimulation. It is commonly studied topically for skin and hair research, and via subcutaneous injection in animal models of tissue repair.
Research dose & half-life
- Half-life:
- ~1–2 hours in plasma
- Research dose:
- Topical research formulations: 1–3 mg/mL. Injectable research protocols: 1–2 mg subcutaneous, 3–5x weekly.
Safety & side effects
Topical: usually well tolerated; possible mild irritation, redness, or contact dermatitis — patch test first. Injectable: local site reactions, transient metallic taste, and (rarely) copper-related symptoms (nausea, headache) if overused. Avoid in Wilson's disease or any condition of copper overload. Not for use on broken or infected skin without supervision. Keep away from eyes.