Overview & mechanism
Pinealon is a synthetic tripeptide developed from research on pineal gland peptides. Preclinical studies suggest effects on oxidative stress reduction in neurons, protection against hypoxic damage, and improvements in cognitive markers in aged animal models. It penetrates the blood-brain barrier due to its small size.
Research dose & half-life
- Half-life:
- Very short in plasma; downstream effects last days
- Research dose:
- Common research protocols vary. Low-dose: 1–2 mg daily subcutaneous for 10-day cycles. Mid-range: 3–5 mg daily for 10-day cycles. Higher-end: up to 10 mg daily for 10-day cycles. Typically repeated 2–3x per year.
Safety & side effects
Very limited human safety data. Reported: injection-site reactions, mild headache, sleep changes (some report vivid dreams or lighter sleep — dose earlier in the day if this occurs). Because it acts centrally, use caution with seizure disorders, active psychiatric conditions, or CNS-active medications. Avoid in pregnancy, pediatrics, and any active malignancy.